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Por Reda��o Galileu

22/12/2023 15h25 Atualizado 22/12/2023

Pesquisadores estudaram dados gen�ticos de mais de 1 milh�o de pessoas?? que fazem consumo excessivo de �lcool habitualmente, incluindo indiv�duos com ancestralidades europeia, africana, latino-americana, asi�tica-oriental e sul-asi�tica.

A enorme amostra revelou?? que o consumo problem�tico de bebidas alco�licas pode estar atrelado a uma arquitetura gen�tica compartilhada. A pesquisa foi publicada em?? 7 de dezembro na revista Nature Medicine.

As descobertas podem ajudar na compreens�o gen�tica do uso problem�tico de �lcool, "uma caracter�stica?? que combina transtorno por uso de bebida alco�lica e problemas relacionados ao �lcool avaliados por meio de um question�rio", segundo?? definem os cientistas.

O estudo � liderado por pesquisadores do VA Connecticut Healthcare Center da Escola de Medicina de Yale, nos?? Estados Unidos. A investiga��o se baseou em dados do Million Veteran Program (MVP), que foram combinados com informa��es de muitas?? outras fontes.

"Aproveitando as informa��es de multiancestralidade, identificamos 110 regi�es gen�ticas e tivemos um mapeamento fino aprimorado das variantes causais potenciais?? em cada regi�o", disse o autor principal do estudo, Hang Zhou, professor assistente na Escola de Medicina de Yale, em?? comunicado.

A pesquisa � a maior at� o momento para o uso problem�tico do �lcool, com muitos genes de risco descobertos.?? Os cientistas usaram v�rios m�todos, incluindo an�lises em 13 tecidos cerebrais e estudos da intera��o de cromatina no c�rebro (um?? complexo de DNA, RNA e prote�nas).

"Um dos produtos mais importantes desta pesquisa � a informa��o fornecida sobre o risco de?? uso problem�tico do �lcool em todo o genoma", disse Joel Gelernter, autor s�nior do estudo. Ele afirma que os resultados?? permitiram at� mesmo sugerir alguns medicamentos j� aprovados que podem se tornar ferramentas para tratar este quadro no futuro, ap�s?? novas pesquisas.

Al�m de servir para identificar tratamentos, o estudo calculou "pontua��es de risco polig�nico" (PRS, na sigla em ingl�s), possivelmente?? �teis para estimar o risco gen�tico de cada pessoa em consumir abusivamente �lcool.

Embora o PRS que os pesquisadores calcularam n�o?? esteja pronto para uso cl�nico, eles testaram os resultados em centenas de caracter�sticas m�dicas de v�rios biobancos norte-americanos, incluindo o?? Biobanco da Universidade Vanderbilt, BioMe do Mount Sinai, Biobanco do Mass General Brigham e Biobanco da Penn Medicine.

"Este estudo avan�a?? nosso conhecimento sobre a etiologia gen�tica do consumo problem�tico de �lcool, e essas descobertas podem trazer uma poss�vel aplicabilidade cl�nica?? das percep��es gen�ticas, juntamente com a neuroci�ncia, a biologia e a ci�ncia de dados", conclu�ram os autores.

Pesquisadores apontam evid�ncias de?? transforma��es na plataforma continental australiana e como mudan�as no n�vel do mar afetaram seu povoamento

Pesquisa analisou como a preval�ncia de?? diabetes, hipertens�o e doen�a renal cr�nica tem rela��o com indicadores de racismo estrutural a partir de dados de bairros de?? uma cidade nos Estados Unidos

Estudo com dados de mais de 1 milh�o de pessoas sugere medicamentos j� aprovados que poder�o?? tratar uso arriscado e frequente de bebidas alco�licas no futuro

Estudo descobriu que, assim como nos roedores, l�grimas humanas cont�m sinal?? qu�mico que bloqueia comportamento violento em homens; saiba mais

Segundo estudo, rean�lises sobre f�sseis sugerem que H.sapiens estava na Europa h�?? pelo menos 210 mil anos � mais de 150 mil anos antes do que se pensava

Ap�s d�cadas de mist�rio, cientistas?? constataram que f�sseis da fam�lia "Burseraceae" s�o anteriores at� mesmo ao impacto do asteroide que deu fim ao Cret�ceo h�?? cerca de 65 milh�es de anos

V�deo mostra esses raios invis�veis, que s�o a forma de luz de maior energia do?? Universo, a partir de dados do Telesc�pio Espacial de Raios Gama Fermi, da Nasa

Telesc�pio mais avan�ado de todos mostrou, sete?? anos desde observa��o com Telesc�pio Hubble, que havia duas explos�es estelares em gal�xia distante � e n�o apenas uma

Chamado "Limnonectes?? phyllofoli", anf�bio tem um h�bito "diferent�o" na hora de proteger seus ovos; trata-se de menor r� com presas j� encontrada?? no mundo

F�ssil descoberto por ve�culo remoto de expedi��o cient�fica perto do Hava�, a mais de 3 mil metros de profundidade,?? tinha a ponta quebrada e bordas serrilhadas; saiba mais

� 1996 - 2023. Todos direitos reservados a Editora Globo S/A. Este?? material n�o pode ser publicado, transmitido por broadcast, reescrito ou redistribu�do sem autoriza��o.


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Gary Sanderson
Affiliations
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Status
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Birth
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Since the release of Call of Duty: Mobile has brought exciting gaming experiences?? for millions of gamers, it also comes with another question: can you play COD Mobile on PC? The answer is?? yes! There is no doubt that you can play this game on your computer, including your Windows PC/laptop and your?? MacBook.

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